BDBM50506236 4sc-201::BYK-408740::BYK408740::RAS-2410::RAS2410::Resminostat

SMILES CN(C)Cc1ccc(cc1)S(=O)(=O)n2ccc(c2)/C=C/C(=O)NO

InChI Key InChIKey=FECGNJPYVFEKOD-UHFFFAOYSA-N

Data  4 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50506236   

TargetHistone deacetylase 1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50506236(4sc-201 | BYK-408740 | BYK408740 | RAS-2410 | RAS2...)
Affinity DataIC50: 43nMAssay Description:Inhibition of C-terminal Flag-tagged HDAC1 (unknown origin) expressed in HEK293 cells or Sf21 cells using Ac-NH-GGK(Ac)-AMC peptide as substrate meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50506236(4sc-201 | BYK-408740 | BYK408740 | RAS-2410 | RAS2...)
Affinity DataIC50: 72nMAssay Description:Inhibition of recombinant C-terminal FLAG-tagged HDAC6 (unknown origin) using Ac-NH-GGK(Ac)-AMC as substrate measured after 180 mins by fluorescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50506236(4sc-201 | BYK-408740 | BYK408740 | RAS-2410 | RAS2...)
Affinity DataIC50: 72nMAssay Description:Inhibition of C-terminal Flag-tagged HDAC6 (unknown origin) expressed in HEK293 cells or Sf21 cells using Ac-NH-GGK(Ac)-AMC peptide as substrate meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50506236(4sc-201 | BYK-408740 | BYK408740 | RAS-2410 | RAS2...)
Affinity DataIC50: 877nMAssay Description:Inhibition of C-terminal Flag-tagged HDAC1 (unknown origin) expressed in HEK293 cells or Sf21 cells using Ac-RHK(Ac)K(Ac)-AMC peptide as substrate me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed