BDBM50652789 A-486
SMILES CNC(=O)Nc1ccc2c(c1)[C@@]1(CC2)OC(=O)N(CC(=O)N(Cc2ccc(F)cc2)[C@@H](C)C(F)(F)F)C1=O
InChI Key
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 50652789
Affinity DataIC50: 9.03E+3nMAssay Description:Inhibition of N-terminal 6His-Flag tagged CBP-BHC domain (1072 to 1859 residues) (unknown origin) expressed in Sf9 cells using the Bac-to-Bac baculov...More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of p300/CBP in human PC-3 cells assessed as reduction in H3K9Ac level incubated for 3 hrs by Hoechst 33342 staining based high content mic...More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of p300/CBP in human PC-3 cells assessed as reduction in H3K27Ac level incubated for 3 hrs by Hoechst 33342 staining based high content mi...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal 6His-Flag tagged p300-BHC domain (1036 to 1822 residues) (unknown origin) expressed in Sf9 cells using the Bac-to-Bac baculo...More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of p300/CBP in human PC-3 cells assessed as reduction in H3K18Ac level incubated for 3 hrs by Hoechst 33342 staining based high content mi...More data for this Ligand-Target Pair
Affinity DataKd: 2.00E+4nMAssay Description:Binding affinity to recombinant human p300 HAT domain expressed in Escherichia coli BL21-CodonPlus(DE3)-RIL cells assessed as dissociation constant u...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of p300 HAT domain (unknown origin) using Biotin-C6-GRGKGGKGLGKGGAK as substrate pretreated with enzyme for 30 mins followed by incubation...More data for this Ligand-Target Pair