BDBM22988 (5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide::AEA::ANANDAMIDE::Arachidonoyl ethanolamide::Arachidonoyl ethanolamide (AEA)::Arachidonoylethanolamide (AEA)::Arachidonylethanolamide::CHEMBL15848::[14C]Anandamide::[3H]Anandamide

SMILES CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCCO

InChI Key InChIKey=LGEQQWMQCRIYKG-UHFFFAOYSA-N

Data  71 KI  11 IC50  1 Kd  7 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 90 hits for monomerid = 22988   

TargetCannabinoid receptor 1(Human)
Universita Del Piemonte Orientale

LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  11nM ΔG°:  -11.0kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataEC50:  16nMAssay Description:Agonist activity at TRPV1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Saint Louis University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]CP-55940 binding to Cannabinoid receptor 1 in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1/2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  25nMAssay Description:Binding affinity towards cannabinoid receptor using [3H]CP-55940 as radioligand in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetCB1 cannabinoid receptor-interacting protein 1(Duck leech)
State University of New York At Old Westbury

Curated by PDSP Ki Database
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  33.3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Medicinal leech)
State University of New York At Old Westbury

Curated by PDSP Ki Database
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  35.8nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Saint Louis University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  39nMAssay Description:In vitro binding affinity was determined against rat brain Cannabinoid receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Mouse)
University of California

Curated by ChEMBL
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataIC50: 39nMAssay Description:Binding affinity towards Cannabinoid receptor 1 was determined using [3H]-CP- cannabinoid as radioligand with mouse brain membrane in the presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Universita Del Piemonte Orientale

LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  39.2nMAssay Description:Compound was evaluated for its binding affinity towards Cannabinoid receptor 1 [Inactive form(R) of CB1 receptor]More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Saint Louis University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataIC50: 40nMAssay Description:Binding affinity towards Cannabinoid receptor 1 was determined using [3H]-CP- cannabinoid as radioligand with rat brain membrane in the presence of P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Universita Del Piemonte Orientale

LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  50nMAssay Description:Binding affinity for human cannabinoid receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Universita Del Piemonte Orientale

LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  50nMAssay Description:Binding affinity to CB1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCannabinoid receptor 1/2(Mouse)
Hebrew University

Curated by ChEMBL
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  52nMAssay Description:Ability to displace [3H]HU-243 binding to cannabinoid receptor in synaptosomal membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Saint Louis University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  61nMAssay Description:Binding affinity towards cannabinoid receptor 1 from rat forebrain membranes in the presence of phenylmethanesulfonylfluoride (PMSF) using 0.8 nM [3H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Saint Louis University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataEC50:  69nMAssay Description:Agonist activity at rat CB1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Universita Del Piemonte Orientale

LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  70nMAssay Description:Displacement of [3H]CP-55-940 from human recombinant CB1 receptor expressed in COS cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Universita Del Piemonte Orientale

LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  70nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in human HEK293 cells in presence of 100 nM PMSFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Universita Del Piemonte Orientale

LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  70nMAssay Description:Displacement of [3H]CP-55-940 from human recombinant CB1 receptor in COS cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Universita Del Piemonte Orientale

LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  70nMAssay Description:Binding affinity to human recombinant CB1 receptor expressed in COS cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Universita Del Piemonte Orientale

LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  72nMAssay Description:Displacement of [3H]CP-55940 from human CB1 receptor expressed in COS cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Universita Del Piemonte Orientale

LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  72nMAssay Description:Displacement of [3H]CP-55,940 from human recombinant CB1 receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Universita Del Piemonte Orientale

LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  72nMAssay Description:Displacement of [3H]-CP55940 from human recombinant CB1 receptor expressed in HEK cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Universita Del Piemonte Orientale

LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  72nMAssay Description:Displacement of [3H]CP-55940 from human recombinant CB1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Universita Del Piemonte Orientale

LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  72nMAssay Description:Displacement of [3H]CP-55940 from human CB1 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Universita Del Piemonte Orientale

LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  72nMAssay Description:Binding affinity to human recombinant CB1 receptor expressed in african green monkey COS cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Saint Louis University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  72nMAssay Description:Inhibition of [3H]CP-55940 binding to rat cannabinoid receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Saint Louis University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  74nMAssay Description:Displacement of [3H]CP-55,940 from CB1 receptor in rat brain membranes in presence of FAAH inhibitor PMSF by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Saint Louis University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  78nMAssay Description:Tested for binding affinity to Cannabinoid receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1/2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  78nMAssay Description:Binding affinity for the cannabinoid receptor in the presence of phenylmethanesulfonyl fluoride (PMSF) was determined in rat fore brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Saint Louis University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  78nMAssay Description:Displacement of [3H]CP-55940 from Cannabinoid receptor 1 of rat forebrain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Saint Louis University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  89nMAssay Description:The compound was tested for Ki value against rat whole brain P2 membrane preparation in presence of enzyme inhibitor PMSF.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Saint Louis University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  89nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details
PubMed
TargetCannabinoid receptor 1(Human)
Universita Del Piemonte Orientale

LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  89nMAssay Description:Binding affinity to CB1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Universita Del Piemonte Orientale

LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  89nMAssay Description:Binding affinity towards cloned human Cannabinoid receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Saint Louis University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  89nMAssay Description:Displacement of [3H]CP55940 from CB1 receptor in Wistar rat brain incubated for 60 mins by radioactive filter binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Mouse)
University of California

Curated by ChEMBL
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  89nMAssay Description:Binding affinity for Cannabinoid receptor 1 in presence of phenylmethylsulfonyl fluoride (PMSF)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Universita Del Piemonte Orientale

LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  89nMAssay Description:Binding affinity to human CB1 receptor in presence of serine protease inhibitor PMSFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Saint Louis University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  90nMAssay Description:Binding affinity towards Cannabinoid receptor 1 in rat forebrain membranes using [3H]CP-55940 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Saint Louis University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  90nMAssay Description:Displacement of [3H]CP-55940 from rat forebrain membrane which expresses Cannabinoid receptor 1 in the presence of PMSFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFatty acid-binding protein 5-ANS(Mouse)
Case Western Reserve University School of Medicine

LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKd:  100nMAssay Description:The method entails two steps [Lin et al., Biochemistry, 38:185-190]. In the first step, the Kd for association of FABP5 with the fluorescent lipid pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details Article
PubMed
TargetFatty acid-binding protein, liver(Mouse)
Avanti Polar Lipids

LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  111nMAssay Description:The following fluorescent ligand displacement assays at 24 °C were used to further confirm and/or determine if the cytosolic lipidic ligand "chaperon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2016
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Saint Louis University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  132nMAssay Description:Displacement of [3H]SR141716A from CB1 receptor in rat cerebellar membrane after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  160nMAssay Description:Displacement of [3H]CP-55,940 from human CB2 receptor expressed in HEK293 cell membranes in absence of FAAH inhibitor PMSF by radioligand binding ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  168nM ΔG°:  -9.39kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2009
Entry Details Article
PubMed
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  169nMAssay Description:Binding affinity to vanilloid VR1 receptor using [3H]resiniferatoxin ([3H]-RTX) in rat spinal cord membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  180nMAssay Description:Displacement of [3H]CP-55940 from human recombinant CB2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  180nMAssay Description:Displacement of [3H]CP-55-940 from human recombinant CB2 receptor expressed in COS cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  180nMAssay Description:Displacement of [3H]CP-55-940 from human recombinant CB2 receptor in COS cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataKi:  180nMAssay Description:Binding affinity to human recombinant CB2 receptor expressed in COS cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataEC50:  200nMAssay Description:The effect of the substances on Ca2+ influx was determined by using HEK-293 cells stably overexpressing recombinant human TRPV1 cDNA. The cells were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2009
Entry Details Article
PubMed
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