BDBM50322823 (S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide::AFATINIB::CHEMBL1173655::US10085983, Compound BIBW2992::US10196365, Afatinib::US10435400, Compound BIBW2992::US11896597, Compound Afatinib::US20240358711, Compound Afatanib::US9388170, Afatinib::US9890168, Compound BIBW2992::WO2022090481, Example afatinib
SMILES CN(C)C/C=C/C(=O)Nc1cc2c(cc1O[C@H]3CCOC3)ncnc2Nc4ccc(c(c4)Cl)F
InChI Key InChIKey=ULXXDDBFHOBEHA-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 641 hits for monomerid = 50322823
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of human N-terminal GST-tagged EGFR L858R mutant (669 to 1210 residues) expressed in baculovirus infected Sf9 insect cells using TK as sub...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 0.0100nMAssay Description:Inhibition of human N-terminal GST-tagged EGFR (669 to 1210 residues) expressed in baculovirus infected Sf9 insect cells using TK as substrate preinc...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0200nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0200nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of wild type EGFR (unknown origin) pre-incubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by m...More data for this Ligand-Target Pair
Affinity DataKd: 0.100nMAssay Description:Binding constant for EGFR(G719C) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.110nMAssay Description:Binding constant for EGFR(E746-A750del) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.120nMAssay Description:Binding constant for EGFR(L747-T751del,Sins) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.120nMAssay Description:Binding constant for EGFR(L747-S752del, P753S) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.140nMAssay Description:Binding constant for EGFR(S752-I759del) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.140nMAssay Description:Binding constant for EGFR(L747-E749del, A750P) kinase domainMore data for this Ligand-Target Pair
Affinity DataIC50: 0.161nMAssay Description:Inhibition of EGFR A763-Y764 ins FQEA mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.166nMAssay Description:Inhibition of EGFR D770-N771 ins NPG mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 0.190nMAssay Description:Binding constant for EGFR(G719S) kinase domainMore data for this Ligand-Target Pair
Affinity DataIC50: 0.190nMAssay Description:Inhibition of wild type EGFR (unknown origin) expressed in baculovirus expression system using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELIS...More data for this Ligand-Target Pair
Affinity DataKd: 0.200nMAssay Description:Binding constant for EGFR(L858R) kinase domainMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human N-terminal GST tagged EGFR L858R mutant (669 to 1210 residues) expressed in insect expression system using peptide as...More data for this Ligand-Target Pair
Affinity DataKd: 0.230nMAssay Description:Binding constant for EGFR(L861Q) kinase domainMore data for this Ligand-Target Pair
Affinity DataIC50: 0.240nMAssay Description:Inhibition of N-terminal GST-fused human wild type EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system using 5-...More data for this Ligand-Target Pair
Affinity DataKd: 0.25nMAssay Description:Binding constant for EGFR kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.25nMAssay Description:Binding affinity to wild-type human partial length EGFR (R669 to V1011 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.259nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.280nMAssay Description:Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669-1210 AA) expressed in baculovirus using FAM-labelled peptide as substrate pre-...More data for this Ligand-Target Pair
Affinity DataIC50: 0.280nMAssay Description:Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669-1210 AA) expressed in baculovirus using FAM-labelled peptide as substrate pre-...More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human N-terminal GST-tagged EGFR L858R/T790M mutant (669 to 1210 residues) expressed in baculovirus infected Sf9 insect cells using TK ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.330nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged EGFR (669 to 1210 residues) expressed in Sf21 insect cells using kinase substrate 22 incubated ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant GST-tagged EGFR L858R mutant using pEY as substrate incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using pEY (4:1) as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of wild-type EGFR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human GST-fused EGFR kinase domain expressed in baculovirus expression system measured after 30 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human wild type EGFR using pEY (4:1) as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human wild type GST-tagged EGFR kinase domain expressed in insect Sf9 cells using pEY (4:1)/biotinylated pEY as substrate after 30 mins...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of wild type EGFR (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of wild-type EGFR phosphorylation (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human wild type GST-tagged EGFR kinase domain expressed in insect Sf9 cells using pEY (4:1)/biotinylated pEY as substrate after 30 mins...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human recombinant GST-tagged EGFR using pEY as substrate incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Irreversible inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.570nMAssay Description:Inhibition of EGFR exon 19 deletion activating mutant phosphorylation in human PC9 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Affinity DataKd: 0.610nMAssay Description:Binding constant for EGFR(T790M) kinase domainMore data for this Ligand-Target Pair
Affinity DataIC50: 0.641nMAssay Description:Inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair