BDBM50220052 (alcuronium)(1R,11S,18S,20R,21R,22S)-12-oxa-17-azonia-8-azaheptacyclo[15.5.2.01,18.02,7.08,22.011,21.015,20]tetracosa-2(7),3,5,14-tetraen-9-one::ALCURONIUM::CHEMBL428492

SMILES C=CC[N+]12CCC34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8[C@@]9(CC[N+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/C(CC31)/C(=C\CO)C2)[C@H]54)[C@@H]69

InChI Key InChIKey=MUQUYTSLDVKIOF-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50220052   

TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Copenhagen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50220052BDBM50220052(CHEMBL428492 | (alcuronium)(1R,11S,18S,20R,21R,22S...)
Affinity DataKi:  1.10E+3nMAssay Description:Displacement of [3H]methyllycaconitine from alpha7 nAChR in tsA201 cells co-expressed with Ric3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Copenhagen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50220052BDBM50220052(CHEMBL428492 | (alcuronium)(1R,11S,18S,20R,21R,22S...)
Affinity DataKi:  2.00E+3nMAssay Description:Displacement of [3H]methyllycaconitine from human alpha-7 in tsA201 cells coexpressed with 5HT3A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Copenhagen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50220052BDBM50220052(CHEMBL428492 | (alcuronium)(1R,11S,18S,20R,21R,22S...)
Affinity DataIC50: 4.10E+3nMAssay Description:Antagonist activity at human alpha-7 nAChR in tsA201 cells coexpressed with Ric3 by FMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
University of Copenhagen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50220052BDBM50220052(CHEMBL428492 | (alcuronium)(1R,11S,18S,20R,21R,22S...)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at human 5HT3A receptor expressed in HEK293 cells by FMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
University of Copenhagen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50220052BDBM50220052(CHEMBL428492 | (alcuronium)(1R,11S,18S,20R,21R,22S...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]GR65630 from human 5HT3A receptor in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Human)
University of Copenhagen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50220052BDBM50220052(CHEMBL428492 | (alcuronium)(1R,11S,18S,20R,21R,22S...)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at human glycine alpha-1 receptor in HEK293 cells by FMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed