BDBM19214 (1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydroxyacetyl)-2-methyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-ene-15-carbaldehyde::Aldosterone::US10188667, Aldosterone::[3H]Aldosterone

SMILES [H][C@@]12CC[C@H](C(=O)CO)[C@]1(C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C)C=O

InChI Key InChIKey=PQSUYGKTWSAVDQ-ZVIOFETBSA-N

Data  1 KI  5 IC50  2 Kd  5 EC50

PDB links: 3 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 19214   

TargetCorticosteroid-binding globulin(Human)
Nippon Zoki Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM19214((1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydro...)
Affinity DataKi:  525nMAssay Description:Binding affinity to human CBG receptor (corticosteroid-binding globulins)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMineralocorticoid receptor(Rat)
Kaken Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM19214((1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydro...)
Affinity DataIC50:  43nMAssay Description:Displacement of [3H]aldosterone from Sprague-Dawley rat MR by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetMineralocorticoid receptor(Rat)
Kaken Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM19214((1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydro...)
Affinity DataIC50:  43nMAssay Description:Displacement of [3H]Aldo from mineralocorticoid receptor in Sprague-Dawley rat kidney after 2 hrs by liquid scintillation countingChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSex hormone-binding globulin(Human)
University of British Columbia

Curated by ChEMBL
LigandPNGBDBM19214((1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydro...)
Affinity DataKd:  4.79E+3nMAssay Description:Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMineralocorticoid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM19214((1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydro...)
Affinity DataEC50:  3.80nMAssay Description:Agonist activity at mineralocorticoid receptor ligand binding domain expressed in african green monkey COS7 cells co-transfected with Gal4-LBD by luc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetMineralocorticoid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM19214((1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydro...)
Affinity DataEC50:  0.338nMAssay Description:Agonist activity at mineralocorticoid receptor-LBD in human U2OS cells transfected with Gal4-DBD assessed as increase of transactivation activity aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetMineralocorticoid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM19214((1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydro...)
Affinity DataEC50:  0.600nMAssay Description:Agonist activity at human MR expressed in CHO-K1 cells by PathHunter assayMore data for this Ligand-Target Pair
In DepthDetails PubMedPDB3D3D Structure (crystal)

TargetAndrogen receptor(Rat)
University of Basel

Curated by ChEMBL
LigandPNGBDBM19214((1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydro...)
Affinity DataIC50: >4.27E+4nMAssay Description:Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMineralocorticoid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM19214((1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydro...)
Affinity DataEC50:  0.470nMAssay Description:Mineralocorticoid receptor (MR) activation potency was assessed using a HEK 293T cell line containing the UAS-bla reporter (UAS-bla HEK 293T CELLSENS...More data for this Ligand-Target Pair
In DepthDetails US Patent
PDB3D3D Structure (crystal)

TargetMineralocorticoid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM19214((1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydro...)
Affinity DataKd:  0.5nMAssay Description:Binding affinity to MR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetMineralocorticoid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM19214((1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydro...)
Affinity DataIC50:  0.305nMAssay Description:Agonist activity at GAL4 DNA-binding domain fused MR (unknown origin) ligand binding domain expressed in UAS-bla H cells assessed as beta-lactamase t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetMineralocorticoid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM19214((1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydro...)
Affinity DataEC50:  0.180nMAssay Description:Agonist activity at human MCR expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetMineralocorticoid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM19214((1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydro...)
Affinity DataIC50:  9.27nMAssay Description:Antagonist activity at mineralocorticoid receptor-LBD in human U2OS cells transfected with Gal4-DBD assessed as inhibition of transactivation activit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)