BDBM101829 US10696661, Compound 74::US9695160, 42::US9796707, Compound 42

SMILES O=C(Nc1cc(C(F)(F)F)ccc1N1CCN(Cc2c[nH]c3ccccc23)CC1)c1ccc(-c2ccncc2)o1

InChI Key InChIKey=PXTGGKHRMSAKSB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 101829   

TargetSRSF protein kinase 1(Human)
The University of Nottingham

US Patent
LigandChemical structure of BindingDB Monomer ID 101829BDBM101829(US9695160, 42 | US9796707, Compound 42 | US1069666...)
Affinity DataIC50: 164nMT: 2°CAssay Description:Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2018
Entry Details
US Patent

TargetSRSF protein kinase 1(Human)
The University of Nottingham

US Patent
LigandChemical structure of BindingDB Monomer ID 101829BDBM101829(US9695160, 42 | US9796707, Compound 42 | US1069666...)
Affinity DataIC50: 164nMAssay Description:Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent

TargetSRSF protein kinase 1(Human)
The University of Nottingham

US Patent
LigandChemical structure of BindingDB Monomer ID 101829BDBM101829(US9695160, 42 | US9796707, Compound 42 | US1069666...)
Affinity DataIC50: 164nMAssay Description:Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent