BDBM102136 US8530648, 6

SMILES O=C1N(Cc2ccccc2)CCCC11CCN(CC1)c1cnc2ccccc2n1

InChI Key InChIKey=GFXQGGGPTWXAKG-UHFFFAOYSA-N

Data  4 KI  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 102136   

TargetOrexin receptor type 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM102136(US8530648, 6)
Affinity DataKi:  182nMAssay Description:Antagonist activity at human OX2 receptor expressed in HEK cells assessed as inhibition of orexin A-induced Ca2+ accumulation after 1 hr by Fluo-4-AM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetOrexin receptor type 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM102136(US8530648, 6)
Affinity DataKi:  371nMpH: 7.4Assay Description:FLIPR assay using orexin receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin/Hypocretin receptor type 1(Human)
Novartis

US Patent
LigandPNGBDBM102136(US8530648, 6)
Affinity DataKi:  1.48E+3nMpH: 7.4Assay Description:FLIPR assay using orexin receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin/Hypocretin receptor type 1(Human)
Novartis

US Patent
LigandPNGBDBM102136(US8530648, 6)
Affinity DataKi:  1.55E+3nMAssay Description:Antagonist activity at human OX1 receptor expressed in CHO cells assessed as inhibition of orexin A-induced Ca2+ accumulation after 1 hr by Fluo-4-AM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetOrexin/Hypocretin receptor type 1(Human)
Novartis

US Patent
LigandPNGBDBM102136(US8530648, 6)
Affinity DataKd:  1.31E+3nMpH: 7.5Assay Description:Radioligand binding assay using orexin receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin receptor type 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM102136(US8530648, 6)
Affinity DataKd:  300nMpH: 7.5Assay Description:Radioligand binding assay using orexin receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent