BDBM10295 4-nitro-N-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-7-yl)benzamide::Isoquinoline-1,3,4-trione 14c::N-(1,2,3,4-Tetrahydro-1,3,4-trioxoisoquinolin-7-yl)-4-nitrobenzamide

SMILES O=C(Nc1ccc2C(=O)C(=O)NC(=O)c2c1)c1ccc(cc1)N(=O)=O

InChI Key InChIKey=NGYGGBLAVBSGBJ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 10295   

TargetCaspase-3(Human)
Shanghai Institutes For Biological Sciences

LigandPNGBDBM10295(4-nitro-N-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquino...)
Affinity DataIC50:  1.38E+3nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCaspase-2(Human)
Shanghai Institutes For Biological Sciences

LigandPNGBDBM10295(4-nitro-N-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquino...)
Affinity DataIC50:  5.67E+3nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCaspase-8(Human)
Shanghai Institutes For Biological Sciences

LigandPNGBDBM10295(4-nitro-N-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquino...)
Affinity DataIC50:  2.47E+4nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCaspase-7(Human)
Shanghai Institutes For Biological Sciences

LigandPNGBDBM10295(4-nitro-N-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquino...)
Affinity DataIC50:  2.71E+3nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCaspase-6(Human)
Shanghai Institutes For Biological Sciences

LigandPNGBDBM10295(4-nitro-N-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquino...)
Affinity DataIC50:  2.85E+3nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed