BDBM106296 US8575197, II-209

SMILES COc1ccccc1C1c2c(n[nH]c2C(C)(C)C)C(=O)N1c1ccc(-c2ncco2)cc1

InChI Key InChIKey=LWHAQVIKMODEMM-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 106296   

TargetP2X purinoceptor 3(Human)
Shionogi

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 106296BDBM106296(US8575197, II-209)
Affinity DataIC50: 87nMAssay Description:Antagonist activity at human P2X3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetP2X purinoceptor 3(Human)
Shionogi

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 106296BDBM106296(US8575197, II-209)
Affinity DataIC50: 87nMAssay Description:Inhibition assay using human P2X3 receptor gene (GeneBank accession number Y07683).More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2014
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Shionogi

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 106296BDBM106296(US8575197, II-209)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Shionogi

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 106296BDBM106296(US8575197, II-209)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Shionogi

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 106296BDBM106296(US8575197, II-209)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed