BDBM10646 2-arylpurine deriv. 11::4-{6-[(2-methoxyethyl)amino]-9-(propan-2-yl)-9H-purin-2-yl}-N-methylbenzamide

SMILES CNC(=O)c1ccc(cc1)-c1nc(NCCOC)c2ncn(C(C)C)c2n1

InChI Key InChIKey=AJMJJTGESUBGFD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 10646   

LigandPNGBDBM10646(4-{6-[(2-methoxyethyl)amino]-9-(propan-2-yl)-9H-pu...)
Affinity DataIC50: 1.80E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Institut Curie

LigandPNGBDBM10646(4-{6-[(2-methoxyethyl)amino]-9-(propan-2-yl)-9H-pu...)
Affinity DataIC50: 3.10E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2006
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Rat)
Institut Curie

LigandPNGBDBM10646(4-{6-[(2-methoxyethyl)amino]-9-(propan-2-yl)-9H-pu...)
Affinity DataIC50: 1.00E+5nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2006
Entry Details Article
PubMed