BDBM106906 US8592455, 106

SMILES N[C@H]1CCC[C@H](C1)c1ccncc1NC(=O)c1nc(ccc1N)C1CCCCC1

InChI Key InChIKey=AKRXLINEJRYTHQ-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 106906   

TargetSerine/threonine-protein kinase pim-1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106906(US8592455, 106)
Affinity DataKi:  5nMAssay Description:Inhibition of PIM1 kinase (unknown origin) using NH2-AGAGRSRHSSYPAGT-OH as substrate by kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106906(US8592455, 106)
Affinity DataIC50: 5nMpH: 7.5Assay Description:The activity of PIM1, PIM2, and PIM3 is measured using a luciferase-luciferin based ATP detection reagent to quantify ATP depletion resulting from ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
Novartis

US Patent
LigandPNGBDBM106906(US8592455, 106)
Affinity DataIC50: 14nMpH: 7.5Assay Description:The activity of PIM1, PIM2, and PIM3 is measured using a luciferase-luciferin based ATP detection reagent to quantify ATP depletion resulting from ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
Novartis

US Patent
LigandPNGBDBM106906(US8592455, 106)
Affinity DataKi:  14nMAssay Description:Inhibition of PIM3 kinase (unknown origin) using NH2-AGAGRSRHSSYPAGT-OH as substrate by kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Novartis

US Patent
LigandPNGBDBM106906(US8592455, 106)
Affinity DataIC50: 22nMpH: 7.5Assay Description:The activity of PIM1, PIM2, and PIM3 is measured using a luciferase-luciferin based ATP detection reagent to quantify ATP depletion resulting from ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Novartis

US Patent
LigandPNGBDBM106906(US8592455, 106)
Affinity DataKi:  23nMAssay Description:Inhibition of PIM2 kinase (unknown origin) using NH2-AGAGRSRHSSYPAGT-OH as substrate by kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed