BDBM107244 US8598345, 200::US8598345, Table 1-30/2-4

SMILES Cc1csc(NC(=O)c2cc(Oc3cncnc3)ccn2)n1

InChI Key InChIKey=HQSAJPPYHDESIU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 107244   

TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt University

US Patent
LigandPNGBDBM107244(US8598345, 200 | US8598345, Table 1-30/2-4)
Affinity DataIC50: 65nMAssay Description:mGluR5 activity was determined in a cell-based assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2014
Entry Details
US Patent

TargetCytochrome P450 1A2(Human)
Vanderbilt University Institute of Imaging Science

Curated by ChEMBL
LigandPNGBDBM107244(US8598345, 200 | US8598345, Table 1-30/2-4)
Affinity DataIC50: 100nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using tacrine as substrate preincubated for 5 mins followed by NADPH addition measured after 8 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University

US Patent
LigandPNGBDBM107244(US8598345, 200 | US8598345, Table 1-30/2-4)
Affinity DataIC50: 181nMAssay Description:mGluR5 activity was determined in a cell-based assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2014
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University

US Patent
LigandPNGBDBM107244(US8598345, 200 | US8598345, Table 1-30/2-4)
Affinity DataIC50: 200nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University

US Patent
LigandPNGBDBM107244(US8598345, 200 | US8598345, Table 1-30/2-4)
Affinity DataIC50: 200nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2019
Entry Details Article
PubMed