BDBM107674 1-(3-Chloro-4-fluorophenyl)-3-(3-(2-methyl- 6-morpholinopyrimidin-4-ylamino)phenyl)urea (Compound 2)

SMILES Cc1nc(Nc2cccc(NC(=O)Nc3ccc(F)c(Cl)c3)c2)cc(n1)N1CCOCC1

InChI Key InChIKey=AQMQQBLCOUAJDA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 107674   

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Shanghai Institute of Pharmaceutical Industry

LigandPNGBDBM107674(1-(3-Chloro-4-fluorophenyl)-3-(3-(2-methyl- 6-morp...)
Affinity DataIC50: 626nMpH: 7.5 T: 2°CAssay Description:Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Shanghai Institute of Pharmaceutical Industry

LigandPNGBDBM107674(1-(3-Chloro-4-fluorophenyl)-3-(3-(2-methyl- 6-morp...)
Affinity DataIC50: 1.07E+3nMpH: 7.5 T: 2°CAssay Description:Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2014
Entry Details Article
PubMed