BDBM10791 8-(prop-2-yn-1-ylamino)-5,6,7,8-tetrahydronaphthalen-2-yl N-ethyl-N-methylcarbamate::aminotetralin deriv. 27b

SMILES CCN(C)C(=O)Oc1ccc2CCCC(NCC#C)c2c1

InChI Key InChIKey=YGELCAKCNMQGLG-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 10791   

TargetAcetylcholinesterase(Human)
Teva Pharmaceutical Industries

LigandChemical structure of BindingDB Monomer ID 10791BDBM10791(8-(prop-2-yn-1-ylamino)-5,6,7,8-tetrahydronaphthal...)
Affinity DataIC50: 5.24E+4nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Teva Pharmaceutical Industries

LigandChemical structure of BindingDB Monomer ID 10791BDBM10791(8-(prop-2-yn-1-ylamino)-5,6,7,8-tetrahydronaphthal...)
Affinity DataIC50: 5.24E+4nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate preincubated for 60 mins followed by substrate addition by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Rat)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 10791BDBM10791(8-(prop-2-yn-1-ylamino)-5,6,7,8-tetrahydronaphthal...)
Affinity DataIC50: 8.50E+4nMAssay Description:Inhibition of rat brain MAO-A using 14C-5-hydroxytryptamine creatinine disulfate as substrate preincubated for 60 mins followed by substrate addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Rat)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 10791BDBM10791(8-(prop-2-yn-1-ylamino)-5,6,7,8-tetrahydronaphthal...)
Affinity DataIC50: 8.50E+4nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2006
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Rat)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 10791BDBM10791(8-(prop-2-yn-1-ylamino)-5,6,7,8-tetrahydronaphthal...)
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibition of rat brain MAO-B using 14C-phenylethylamine as substrate preincubated for 60 mins followed by substrate addition and measured after 20 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Rat)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 10791BDBM10791(8-(prop-2-yn-1-ylamino)-5,6,7,8-tetrahydronaphthal...)
Affinity DataIC50: 1.20E+5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2006
Entry Details Article
PubMed