BDBM108425 US8609688, 3
SMILES Nc1ncccc1-c1nc2ccc(nc2n1-c1ccc(cc1)C1(N)CCC1)-c1cccc(NC(=O)C2CC2)c1
InChI Key InChIKey=LFVHUYXYEQYBQS-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 108425
Affinity DataIC50: 3.09nMpH: 8.0 T: 25°CAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Lum...More data for this Ligand-Target Pair
Affinity DataIC50: 3.09nMAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...More data for this Ligand-Target Pair
Affinity DataKd: 7nMAssay Description:Binding analysis. Protein-ligand binding was identified with the thermal shift assay which is based on the ligand-induced stabilization of the protei...More data for this Ligand-Target Pair
Affinity DataKd: 7nMpH: 7.5 T: 80°CAssay Description:Protein-ligand binding was identified with the thermal shift assay which is based on the ligand-induced stabilization of the protein tertiary structu...More data for this Ligand-Target Pair