BDBM108435 US8609688, 13
SMILES CCC(=O)N1CCN(CC1)c1cccc(c1)-c1ccc2nc(-c3cccnc3N)n(-c3ccc(cc3)C3(N)CCC3)c2n1
InChI Key InChIKey=RXORTACENZHOOR-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 108435
Affinity DataKd: 1.40nMpH: 7.5 T: 80°CAssay Description:Protein-ligand binding was identified with the thermal shift assay which is based on the ligand-induced stabilization of the protein tertiary structu...More data for this Ligand-Target Pair
Affinity DataIC50: 2.15nMAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...More data for this Ligand-Target Pair
Affinity DataKd: 1.40nMAssay Description:Binding analysis. Protein-ligand binding was identified with the thermal shift assay which is based on the ligand-induced stabilization of the protei...More data for this Ligand-Target Pair
Affinity DataIC50: 2.15nMpH: 8.0 T: 25°CAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Lum...More data for this Ligand-Target Pair