BDBM110700 US8614206, 120::US8614206, 125::US8614206, 400

SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1N1CCCC(N)C(F)C1

InChI Key InChIKey=XFQXLZJUIKQXOU-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 110700   

TargetSerine/threonine-protein kinase pim-3(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM110700(US8614206, 125 | US8614206, 400 | US8614206, 120)
Affinity DataKi:  0.00900nMAssay Description:Inhibition of recombinant human PIM3 using FAM-pimtide as substrate after 90 mins by Z-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM110700(US8614206, 125 | US8614206, 400 | US8614206, 120)
Affinity DataKi:  0.0560nMpH: 7.2Assay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM110700(US8614206, 125 | US8614206, 400 | US8614206, 120)
Affinity DataKi:  0.0800nMAssay Description:Inhibition of recombinant human PIM1 using FAM-pimtide as substrate after 90 mins by Z-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM110700(US8614206, 125 | US8614206, 400 | US8614206, 120)
Affinity DataKi:  0.150nMpH: 7.2Assay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM110700(US8614206, 125 | US8614206, 400 | US8614206, 120)
Affinity DataKi:  0.300nMpH: 7.2Assay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM110700(US8614206, 125 | US8614206, 400 | US8614206, 120)
Affinity DataKi:  0.400nMAssay Description:Inhibition of recombinant human PIM2 using FAM-pimtide as substrate after 90 mins by Z-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed