BDBM11185 (2S,3S)-3-[4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl]-1-oxo-1-(1,3-thiazolidin-3-yl)butan-2-aminium; 2,2,2-trifluoroacetate::pyridone-based inhibitor 28

SMILES C[C@H]([C@H]([NH3+])C(=O)N1CCSC1)c1ccc(cc1)-c1ccc(=O)n(C)c1

InChI Key InChIKey=ZYXUIWSHYKMKKF-UHFFFAOYSA-O

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 11185   

TargetDipeptidyl peptidase 4(Human)
Merck Research Laboratories

LigandPNGBDBM11185((2S,3S)-3-[4-(1-methyl-6-oxo-1,6-dihydropyridin-3-...)
Affinity DataIC50: 26nMpH: 7.5 T: 2°CAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 2(Human)
Merck Research Laboratories

LigandPNGBDBM11185((2S,3S)-3-[4-(1-methyl-6-oxo-1,6-dihydropyridin-3-...)
Affinity DataIC50: 810nMAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Merck Research Laboratories

LigandPNGBDBM11185((2S,3S)-3-[4-(1-methyl-6-oxo-1,6-dihydropyridin-3-...)
Affinity DataIC50: 1.00E+5nMAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 9(Human)
Merck Research Laboratories

LigandPNGBDBM11185((2S,3S)-3-[4-(1-methyl-6-oxo-1,6-dihydropyridin-3-...)
Affinity DataIC50: 1.00E+5nMAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2006
Entry Details Article
PubMed