BDBM112615 US8618103, I-111

SMILES CC(C)CS(=O)(=O)N1C[C@@H](C)C[C@@H](C1)Nc1nc(ncc1-c1cnc2[nH]ccc2n1)N1CCN(C)CC1

InChI Key InChIKey=GCRPKZFLZHBPJI-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 112615   

TargetTyrosine-protein kinase JAK3(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM112615(US8618103, I-111)
Affinity DataKi:  0.0163nM IC50: 0.00519nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM112615(US8618103, I-111)
Affinity DataIC50: 0.0838nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent