BDBM114259 3-[5-[(E)-(1-ketothiazolo[3,2-a]benzimidazol-2-ylidene)methyl]-2-furyl]benzoic acid::3-[5-[(E)-(1-oxidanylidene-[1,3]thiazolo[3,2-a]benzimidazol-2-ylidene)methyl]furan-2-yl]benzoic acid::3-[5-[(E)-(1-oxo-2-thiazolo[3,2-a]benzimidazolylidene)methyl]-2-furanyl]benzoic acid::3-[5-[(E)-(1-oxo-[1,3]thiazolo[3,2-a]benzimidazol-2-ylidene)methyl]furan-2-yl]benzoic acid::3-{5-[3-Oxo-benzo[4,5]imidazo[2,1-b]thiazol-(2E)-ylidenemethyl]-furan-2-yl}-benzoic acid::MLS000777053::SMR000413437::US20230364057, Compound 47::cid_1976940

SMILES OC(=O)c1cccc(c1)-c1ccc(\C=c2\sc3nc4ccccc4n3c2=O)o1

InChI Key InChIKey=IHXPBZYKWITPFM-WOJGMQOQSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 114259   

Target1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [1-999,I813T](Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM114259(3-[5-[(E)-(1-ketothiazolo[3,2-a]benzimidazol-2-yli...)
Affinity DataIC50:  1.22E+5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay

TargetDNA gyrase inhibitor(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM114259(3-[5-[(E)-(1-ketothiazolo[3,2-a]benzimidazol-2-yli...)
Affinity DataIC50:  1.87E+3nMAssay Description:SDFQ HTS primary assay using pAB1_FL905 was performed in 2 µL of (1 xDNA gyrase buffer: 20 mM Tris-Acetate pH 7.9, 50 mM KAc, 10 mM MgCl2, 2 mM DTT, ...More data for this Ligand-Target Pair
In DepthDetails US Patent


Target1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM114259(3-[5-[(E)-(1-ketothiazolo[3,2-a]benzimidazol-2-yli...)
Affinity DataIC50:  1.22E+5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay