BDBM116315 US8637526, 248

SMILES Nc1ccn2ncc(C(=O)Nc3c[nH]nc3-c3cc(Cl)ccc3Cl)c2n1

InChI Key InChIKey=URVFJVXEAYRVCV-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 116315   

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM116315(US8637526, 248)
Affinity DataKi:  0.100nM ΔG°:  -13.5kcal/molepH: 7.2 T: 22°CAssay Description:To determine the inhibition constants (Ki), compounds were diluted serially in DMSO and added to 50 kinase reactions containing 0.2 nM purified JAK2 ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetTyrosine-protein kinase JAK3(Human)
Genentech

US Patent
LigandPNGBDBM116315(US8637526, 248)
Affinity DataKi:  1.70nM ΔG°:  -11.8kcal/molepH: 7.2 T: 22°CAssay Description:To determine inhibition constants (Ki), compounds were diluted serially in DMSO and added to 50 uL kinase reactions containing 5 nM purified JAK3 enz...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM116315(US8637526, 248)
Affinity DataKi:  2.80nMpH: 7.2Assay Description:To determine inhibition constants (Ki), compounds were diluted serially in DMSO and added to 50 uL kinase reactions containing 1.5 nM JAK1, 0.2 nM pu...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Genentech

US Patent
LigandPNGBDBM116315(US8637526, 248)
Affinity DataKi:  4.10nMpH: 7.2Assay Description:To determine inhibition constants (Ki), compounds were diluted serially in DMSO and added to 50 uL kinase reactions containing 1.5 nM JAK1, 0.2 nM pu...More data for this Ligand-Target Pair
In DepthDetails US Patent