BDBM116317 US8637526, 297
SMILES O=C(NC1CCOCC1)c1cnn2ccc(NC3Cc4ccccc4C3)nc12
InChI Key InChIKey=OXTIPRCZMLWKFL-UHFFFAOYSA-N
Data 4 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 116317
Affinity DataKi: 1.60nM ΔG°: -11.9kcal/molepH: 7.2 T: 22°CAssay Description:To determine the inhibition constants (Ki), compounds were diluted serially in DMSO and added to 50 kinase reactions containing 0.2 nM purified JAK2 ...More data for this Ligand-Target Pair
Affinity DataKi: 39.7nM ΔG°: -9.99kcal/molepH: 7.2 T: 22°CAssay Description:To determine inhibition constants (Ki), compounds were diluted serially in DMSO and added to 50 uL kinase reactions containing 5 nM purified JAK3 enz...More data for this Ligand-Target Pair
Affinity DataKi: 46.6nMpH: 7.2Assay Description:To determine inhibition constants (Ki), compounds were diluted serially in DMSO and added to 50 uL kinase reactions containing 1.5 nM JAK1, 0.2 nM pu...More data for this Ligand-Target Pair
Affinity DataKi: 152nMpH: 7.2Assay Description:To determine inhibition constants (Ki), compounds were diluted serially in DMSO and added to 50 uL kinase reactions containing 1.5 nM JAK1, 0.2 nM pu...More data for this Ligand-Target Pair