BDBM116318 US8637526, 299

SMILES O[C@H]1CCC(CC1)NC(=O)c1cnn2ccc(NC3CCc4ccccc34)nc12

InChI Key InChIKey=IJRFYMDEHNCGGT-HKMLXEAFSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 116318   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM116318(US8637526, 299)
Affinity DataKi:  0.800nM ΔG°:  -12.3kcal/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki), compounds were diluted serially in DMSO and added to 50 kinase reactions containing 0.2 nM purified JAK2 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM116318(US8637526, 299)
Affinity DataKi:  14.5nM ΔG°:  -10.6kcal/molepH: 7.2 T: 2°CAssay Description:To determine inhibition constants (Ki), compounds were diluted serially in DMSO and added to 50 uL kinase reactions containing 5 nM purified JAK3 enz...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM116318(US8637526, 299)
Affinity DataKi:  28.7nMpH: 7.2Assay Description:To determine inhibition constants (Ki), compounds were diluted serially in DMSO and added to 50 uL kinase reactions containing 1.5 nM JAK1, 0.2 nM pu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM116318(US8637526, 299)
Affinity DataKi:  50.9nMpH: 7.2Assay Description:To determine inhibition constants (Ki), compounds were diluted serially in DMSO and added to 50 uL kinase reactions containing 1.5 nM JAK1, 0.2 nM pu...More data for this Ligand-Target Pair
In DepthDetails US Patent