BDBM116420 US8637532, 101

SMILES NC(=O)c1cc(O)cc2c(NCc3ccc(cc3)C(F)(F)F)ncnc12

InChI Key InChIKey=ORMLOSONIQIDBI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 116420   

TargetAurora kinase B(Human)
Merck Patent

US Patent
LigandPNGBDBM116420(US8637532, 101)
Affinity DataIC50: 0.240nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetAurora kinase A(Human)
Merck Patent

US Patent
LigandPNGBDBM116420(US8637532, 101)
Affinity DataIC50: 0.320nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetRibosomal protein S6 kinase beta-1(Human)
Merck Patent

US Patent
LigandPNGBDBM116420(US8637532, 101)
Affinity DataIC50: 23.1nMpH: 7.5 T: 2°CAssay Description:P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent