BDBM117063 US8664236, A42::US9238651, A42

SMILES Cn1cc(-c2cnc3[nH]cc(-c4cc(C5(c6ccccc6F)CC5)nc(N)n4)c3c2)cn1

InChI Key InChIKey=CUHXIPDONWEGGN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 117063   

Target3-phosphoinositide-dependent protein kinase 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 117063BDBM117063(US8664236, A42 | US9238651, A42)
Affinity DataIC50: 20nMpH: 8.0 T: 2°CAssay Description:The cellular assay for the determination of the PDK1 kinase activity is carried out as a Luminex assay in the 96-well format. PC3 cells are sown at 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

Target3-phosphoinositide-dependent protein kinase 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 117063BDBM117063(US8664236, A42 | US9238651, A42)
Affinity DataIC50: 45.5nMAssay Description:The compound inhibits the target protein in the enzymatic PDK1 inhibition assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2014
Entry Details
US Patent

Target3-phosphoinositide-dependent protein kinase 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 117063BDBM117063(US8664236, A42 | US9238651, A42)
Affinity DataIC50: 45.5nMT: 2°CAssay Description:The experimental batches are carried out in a flashplate system with 384 wells/microtitration plate.In each case, the PDK1 sample His6-PDK1(Δ1-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent