BDBM124626 US8759366, 1-(5-{3-[(4-tert-butylpyrimidin-2-yl)amino]-5-methylphenyl}-1,3-thiazol-2-yl)-cyclobutanol

SMILES Cc1cc(Nc2nccc(n2)C(C)(C)C)cc(c1)-c1cnc(s1)C1(O)CCC1

InChI Key InChIKey=CHHVBVXIWUUQFI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 124626   

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM124626(US8759366, 1-(5-{3-[(4-tert-butylpyrimidin-2-yl)am...)
Affinity DataIC50: 25nMpH: 7.5 T: 2°CAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2014
Entry Details
US Patent