BDBM124628 US8759366, (1S,4R)-N-(cyanomethyl)-4-hydroxy-2,2-dimethyl-4-(5-{3-methyl-5-[(4-methylpyrimidin-2-yl)amino]phenyl}-1,3-thiazol-2-yl)cyclohexanecarboxamide

SMILES Cc1cc(Nc2nccc(C)n2)cc(c1)-c1cnc(s1)[C@@]1(O)CC[C@H](C(=O)NCC#N)C(C)(C)C1

InChI Key InChIKey=UPIWXRAMDFHOCU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 124628   

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM124628(US8759366, (1S,4R)-N-(cyanomethyl)-4-hydroxy-2,2-d...)
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2014
Entry Details
US Patent