BDBM124639 US8759366, N-(dicyclopropylmethyl)-N-methyl-5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazole-2-carboxamide

SMILES CN(C(C1CC1)C1CC1)C(=O)c1ncc(s1)-c1cc(C)cc(Nc2nccc(n2)C(F)(F)F)c1

InChI Key InChIKey=NSKZBBZUIGCPIL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 124639   

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM124639(US8759366, N-(dicyclopropylmethyl)-N-methyl-5-(3-m...)
Affinity DataIC50: 1.25E+3nMpH: 7.5 T: 2°CAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2014
Entry Details
US Patent