BDBM124641 US8759366, (1-methyl-1H-pyrazol-5-yl)[5-(3-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}-phenyl)-1,3-thiazol-2-yl]methanol

SMILES Cn1nccc1C(O)c1ncc(s1)-c1cccc(Nc2nccc(n2)C(F)(F)F)c1

InChI Key InChIKey=HCYRDBHQSYCXRB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 124641   

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM124641(US8759366, (1-methyl-1H-pyrazol-5-yl)[5-(3-{[4-(tr...)
Affinity DataIC50: 237nMpH: 7.5 T: 2°CAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2014
Entry Details
US Patent