BDBM124644 US8759366, cis-4-hydroxy-1-methyl-4-[5-(3-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}-phenyl)-1,3-thiazol-2-yl]cyclohexanecarboxylic acid::US8759366, trans-4-hydroxy-1-methyl-4-[5-(3-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}-phenyl)-1,3-thiazol-2-yl]cyclohexanecarboxylic acid

SMILES CC1(CCC(O)(CC1)c1ncc(s1)-c1cccc(Nc2nccc(n2)C(F)(F)F)c1)C(O)=O

InChI Key InChIKey=DSBKXUBJVRREDE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 124644   

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM124644(US8759366, cis-4-hydroxy-1-methyl-4-[5-(3-{[4-(tri...)
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2014
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM124644(US8759366, cis-4-hydroxy-1-methyl-4-[5-(3-{[4-(tri...)
Affinity DataIC50: 4nMpH: 7.5 T: 2°CAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2014
Entry Details
US Patent