BDBM124647 US8759366, 8-[2-(2,2-difluoro-1-hydroxyethyl)-1,3-thiazol-5-yl]-2,2-dimethyl-6-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}-2H-1,4-benzoxazin-3(4H)-one

SMILES CC1(C)Oc2c(NC1=O)cc(Nc1nccc(n1)C(F)(F)F)cc2-c1cnc(s1)C(O)C(F)F

InChI Key InChIKey=PLCKQBLDYMXNRI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 124647   

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM124647(US8759366, 8-[2-(2,2-difluoro-1-hydroxyethyl)-1,3-...)
Affinity DataIC50: 15nMpH: 7.5 T: 2°CAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2014
Entry Details
US Patent