BDBM124649 US8759366, cis-4-[(hydroxyacetyl)amino]-1-[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]cyclohexanecarboxamide

SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(s1)C1(CCC(CC1)NC(=O)CO)C(N)=O

InChI Key InChIKey=GWPUKRNPXCGFPT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 124649   

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM124649(US8759366, cis-4-[(hydroxyacetyl)amino]-1-[5-(3-me...)
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2014
Entry Details
US Patent