BDBM124654 US8759366, N-{3-[2-(1-aminocyclobutyl)-1,3-thiazol-5-yl]-5-methylphenyl}-4-cyclopropyl-pyrimidin-2-amine hydrochloride

SMILES Cc1cc(Nc2nccc(n2)C2CC2)cc(c1)-c1cnc(s1)C1(N)CCC1

InChI Key InChIKey=QUIORPAZCIVCMW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 124654   

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM124654(US8759366, N-{3-[2-(1-aminocyclobutyl)-1,3-thiazol...)
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2014
Entry Details
US Patent