BDBM124657 US8759366, Ethyl (1R,4S)-4-hydroxy-2,2-dimethyl-4-[5-(3-methyl-5-{[4-(trifluoromethyl)-pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]cyclohexanecarboxylate

SMILES CCOC(=O)[C@@H]1CC[C@](O)(CC1(C)C)c1ncc(s1)-c1cc(C)cc(Nc2nccc(n2)C(F)(F)F)c1

InChI Key InChIKey=KNUYDSQWSSZSPE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 124657   

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM124657(US8759366, Ethyl (1R,4S)-4-hydroxy-2,2-dimethyl-4-...)
Affinity DataIC50: 49nMpH: 7.5 T: 2°CAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2014
Entry Details
US Patent