BDBM126993 US8785459, 68

SMILES COc1cc2ncnc(Nc3cccc(O)c3)c2cc1-c1ccc(N)cc1

InChI Key InChIKey=PLMGQLOWNWVITJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 126993   

TargetSerine/threonine-protein kinase B-raf(Human)
Development Center For Biotechnology

US Patent
LigandPNGBDBM126993(US8785459, 68)
Affinity DataIC50: 55.8nMAssay Description:Inhibition of kinase activity by test compound disclosed herein was estimated by quantifying the amount of [33P] incorporation of substrate in the pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Development Center For Biotechnology

US Patent
LigandPNGBDBM126993(US8785459, 68)
Affinity DataIC50: 76.6nMAssay Description:Inhibition of kinase activity by test compound disclosed herein was estimated by quantifying the amount of [33P] incorporation of substrate in the pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2014
Entry Details
US Patent

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Development Center For Biotechnology

US Patent
LigandPNGBDBM126993(US8785459, 68)
Affinity DataIC50: 860nMAssay Description:Inhibition of kinase activity by test compound disclosed herein was estimated by quantifying the amount of [33P] incorporation of substrate in the pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2014
Entry Details
US Patent