BDBM12705 CHEMBL146793::N-[2-fluoro-4-(2-methanesulfonylphenyl)phenyl]-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::N-arylpyrazole carboxamide 3

SMILES COc1ccc(cc1)-n1nc(cc1C(=O)Nc1ccc(cc1F)-c1ccccc1S(C)(=O)=O)C(F)(F)F

InChI Key InChIKey=VLCRCSZZKBAYJK-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 12705   

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM12705(N-[2-fluoro-4-(2-methanesulfonylphenyl)phenyl]-1-(...)
Affinity DataKi:  3.5nM ΔG°:  -11.4kcal/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2006
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM12705(N-[2-fluoro-4-(2-methanesulfonylphenyl)phenyl]-1-(...)
Affinity DataKi:  3.60nMAssay Description:Tested in vitro for inhibition of human Coagulation factor XMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM12705(N-[2-fluoro-4-(2-methanesulfonylphenyl)phenyl]-1-(...)
Affinity DataKi: >2.50E+3nMAssay Description:Tested in vitro for inhibition of human trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM12705(N-[2-fluoro-4-(2-methanesulfonylphenyl)phenyl]-1-(...)
Affinity DataKi: >2.10E+4nMAssay Description:In vitro for inhibition of human thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed