BDBM127455 US8791131, 229

SMILES Cn1c2cnc3ccc(nc3c2n([C@H]2CC[C@H](O)CC2)c1=O)-c1cnc(N)nc1

InChI Key InChIKey=ITCPHICQZLTGMF-JOCQHMNTSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 127455   

LigandPNGBDBM127455(US8791131, 229)
Affinity DataKi:  0.273nM ΔG°:  -13.0kcal/molepH: 7.4 T: 25°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetSerine/threonine-protein kinase mTOR(Human)
Pfizer

US Patent
LigandPNGBDBM127455(US8791131, 229)
Affinity DataKi:  0.330nM ΔG°:  -12.9kcal/molepH: 7.5 T: 25°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In DepthDetails US Patent