BDBM127489 US8791131, 267

SMILES Cn1c2cnc3ccc(nc3c2n([C@H]2CC[C@H](O)CC2)c1=O)-c1ccc2[nH]ncc2c1

InChI Key InChIKey=ZLASBNFOQVWTOW-WKILWMFISA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 127489   

LigandPNGBDBM127489(US8791131, 267)
Affinity DataKi:  0.145nM ΔG°:  -13.4kcal/molepH: 7.4 T: 25°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetSerine/threonine-protein kinase mTOR(Human)
Pfizer

US Patent
LigandPNGBDBM127489(US8791131, 267)
Affinity DataKi:  0.359nM ΔG°:  -12.9kcal/molepH: 7.5 T: 25°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In DepthDetails US Patent