BDBM127490 US8791131, 268

SMILES Cn1c2cnc3ccc(nc3c2n([C@H]2CC[C@H](O)CC2)c1=O)-c1cnc2[nH]ncc2c1

InChI Key InChIKey=SRIMYUDGKMDALL-SHTZXODSSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 127490   

TargetSerine/threonine-protein kinase mTOR(Human)
Pfizer

US Patent
LigandPNGBDBM127490(US8791131, 268)
Affinity DataKi:  0.117nM ΔG°:  -13.5kcal/molepH: 7.5 T: 25°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In DepthDetails US Patent


LigandPNGBDBM127490(US8791131, 268)
Affinity DataKi:  0.366nM ΔG°:  -12.9kcal/molepH: 7.4 T: 25°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent