BDBM127775 US10251889, Example 148::US10758542, Example 148::US8791123, 148::US9782415, Example 148

SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NCCCO)c2n1

InChI Key InChIKey=VTUVGNKQBUVKIW-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 127775   

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandPNGBDBM127775(US8791123, 148 | US9782415, Example 148 | US102518...)
Affinity DataIC50: 1.10nMpH: 7.5Assay Description:An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2014
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandPNGBDBM127775(US8791123, 148 | US9782415, Example 148 | US102518...)
Affinity DataIC50: 1.10nMAssay Description:An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Array Biopharm

US Patent
LigandPNGBDBM127775(US8791123, 148 | US9782415, Example 148 | US102518...)
Affinity DataIC50: 1.10nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandPNGBDBM127775(US8791123, 148 | US9782415, Example 148 | US102518...)
Affinity DataIC50: 1.10nMAssay Description:An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Array Biopharma

US Patent
LigandPNGBDBM127775(US8791123, 148 | US9782415, Example 148 | US102518...)
Affinity DataIC50: 1.00E+3nMAssay Description:Jak2: Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mix...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Array Biopharm

US Patent
LigandPNGBDBM127775(US8791123, 148 | US9782415, Example 148 | US102518...)
Affinity DataIC50: 1.00E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2014
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Array Biopharm

US Patent
LigandPNGBDBM127775(US8791123, 148 | US9782415, Example 148 | US102518...)
Affinity DataIC50: 1.00E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandPNGBDBM127775(US8791123, 148 | US9782415, Example 148 | US102518...)
Affinity DataIC50: 1.00E+3nMAssay Description:An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent