BDBM130921 US8822500, [24A]

SMILES Cc1c2c(cc3[nH]c(-c4c(NC(C)Cc5c(F)c(F)cc(F)c5F)cc[nH]c4=O)nc13)C(=O)N(C1CCN(C)CC1)C2

InChI Key InChIKey=ZUSOUYHYDDCGIC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 130921   

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Chembridge

US Patent
LigandChemical structure of BindingDB Monomer ID 130921BDBM130921(US8822500, [24A])
Affinity DataIC50: 2.37nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Chembridge

US Patent
LigandChemical structure of BindingDB Monomer ID 130921BDBM130921(US8822500, [24A])
Affinity DataIC50: 5.99nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 130921BDBM130921(US8822500, [24A])
Affinity DataIC50: 11.2nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Chembridge

US Patent
LigandChemical structure of BindingDB Monomer ID 130921BDBM130921(US8822500, [24A])
Affinity DataIC50: 14.6nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details
US Patent