BDBM132068 US8841455, 65 Step D

SMILES CN1CCN(CCOc2ccn3c(cnc3c2)C(=O)Nc2cccc3n(Cc4cccc(C)n4)nc(C4CC4)c23)CC1

InChI Key InChIKey=JUPOTOIJLKDAPF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 132068   

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM132068(US8841455, 65 Step D)
Affinity DataIC50: 9nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM132068(US8841455, 65 Step D)
Affinity DataIC50: 93.6nMpH: 7.3 T: 2°CAssay Description:The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2015
Entry Details
US Patent