BDBM132283 US8841312, 26

SMILES c1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C34CC5CC(CC(C5)C3)C4)c2cn1

InChI Key InChIKey=DSNHCXNKKZEERJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 132283   

TargetCyclin-dependent kinase 4(Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 132283BDBM132283(US8841312, 26)
Affinity DataIC50: 1.60nMpH: 7.4 T: 2°CAssay Description:The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2015
Entry Details
US Patent

TargetCyclin-dependent kinase 6(Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 132283BDBM132283(US8841312, 26)
Affinity DataIC50: 3.5nMpH: 7.4 T: 2°CAssay Description:The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2015
Entry Details
US Patent