BDBM136193 US8853193, 23-2

SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12)C(O)=O

InChI Key InChIKey=FRGARKJLNFHDAI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 136193   

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM136193(US8853193, 23-2)
Affinity DataIC50:  6nMpH: 7.4 T: 2°CAssay Description:Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM136193(US8853193, 23-2)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of His-tagged Mnk2 (unknown origin) using eIF4E-derived (D 202 TATKSGSTTKNR 214) peptide as substrate incubated for 90 mins by IMAP TR-FRE...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
A*Star

Curated by ChEMBL
LigandPNGBDBM136193(US8853193, 23-2)
Affinity DataIC50:  1.47E+5nMAssay Description:Inhibition of Mnk1 (unknown origin) using eIF4E-derived (D 202 TATKSGSTTKNR 214) peptide as substrate incubated for 90 mins by IMAP TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed