BDBM138225 US8871738, 8

SMILES COc1ccc([C@H]2C[C@H](C(=O)O)C2)cc1-c1ccc(C(F)(F)F)cc1[C@@H]1CC[C@H]2[C@@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)OC(=O)N12

InChI Key InChIKey=VHUXWKLCNFBNEC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 138225   

TargetCholesteryl ester transfer protein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 138225BDBM138225(US8871738, 8)
Affinity DataIC50: 96.5nMpH: 7.4 T: 2°CAssay Description:First, low density lipoprotein (LDL) (Meridian) was biotinylated by incubating LDL with biotin for 1 hour on ice, after which it was dialyzed to remo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2015
Entry Details
US Patent

TargetCytochrome P450 2C8(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 138225BDBM138225(US8871738, 8)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 138225BDBM138225(US8871738, 8)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of Cav1.2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 138225BDBM138225(US8871738, 8)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed