BDBM138310 US8877944, 14
SMILES Cn1cccc1CN1CCC(CC1)N1Cc2cccc(C(N)=O)c2C1=O
InChI Key InChIKey=RQJRYJMBMVWZEY-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 138310
Affinity DataKd: 66nMAssay Description:The assay is based on the use of a probe of formula (IP) that binds to the NAD binding pocket and takes advantage of the significant change in the po...More data for this Ligand-Target Pair
Affinity DataIC50: 1.56E+3nMAssay Description:Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to full length recombinant human PARP-2 by fluorescence polarization displacement assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of PARP1 in human HeLa cells assessed as reduction of H2O2-induced PAR formation preincubated for 30 mins followed by H2O2 addition measur...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataKd: 50nMAssay Description:Binding affinity to full length recombinant human PARP-1 by fluorescence polarization displacement assayMore data for this Ligand-Target Pair