BDBM13922 3-(1H-imidazol-1-yl)propyl 4-[(1-benzyl-1H-indazol-5-yl)amino]-5-ethylpyrrolo[1,2-a][1,2,4]triazine-6-carboxylate::CHEMBL193368::pyrrolo[2,1-f][1,2,4]triazine analog 8a

SMILES CCc1c(cn2ncnc(Nc3ccc4n(Cc5ccccc5)ncc4c3)c12)C(=O)OCCCn1ccnc1

InChI Key InChIKey=CQTPFJKIPFEALQ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 13922   

TargetEpidermal growth factor receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13922(3-(1H-imidazol-1-yl)propyl 4-[(1-benzyl-1H-indazol...)
Affinity DataIC50: 170nMAssay Description:In vitro inhibitory concentration against EGFR cytoplasmic sequence expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13922(3-(1H-imidazol-1-yl)propyl 4-[(1-benzyl-1H-indazol...)
Affinity DataIC50: 170nMAssay Description:Inhibitory concentration against Sal2 (salivary gland carcinoma) cell line expressing active HER2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13922(3-(1H-imidazol-1-yl)propyl 4-[(1-benzyl-1H-indazol...)
Affinity DataIC50: 240nMAssay Description:Inhibitory concentration against Sal2 (salivary gland carcinoma) cell line expressing active HER2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13922(3-(1H-imidazol-1-yl)propyl 4-[(1-benzyl-1H-indazol...)
Affinity DataIC50: 240nMAssay Description:In vitro inhibitory concentration against HER2 cytoplasmic sequence expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13922(3-(1H-imidazol-1-yl)propyl 4-[(1-benzyl-1H-indazol...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibitory concentration against Sal2 (salivary gland carcinoma) cell line expressing active HER2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed