BDBM14059 4-hydroxy-3-[[(3S)-2-oxo-3-(9-thia-5-azabicyclo[4.3.0]nona-2,4,7,10-tetraen-8-ylsulfonylamino)pyrrolidin-1-yl]methyl]benzenecarboximidamide::4-hydroxy-3-{[(3S)-2-oxo-3-{thieno[3,2-b]pyridine-2-sulfonamido}pyrrolidin-1-yl]methyl}benzene-1-carboximidamide::CHEMBL330572::RPR131247

SMILES NC(=N)c1ccc(O)c(CN2CC[C@H](NS(=O)(=O)c3cc4ncccc4s3)C2=O)c1

InChI Key InChIKey=PQJGWYQPOHCEDO-ZDUSSCGKSA-N

Data  9 KI

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 14059   

TargetCoagulation factor X(Human)
Aventis Pharma

LigandPNGBDBM14059(4-hydroxy-3-[[(3S)-2-oxo-3-(9-thia-5-azabicyclo[4....)
Affinity DataKi:  0.700nM ΔG°:  -12.4kcal/molepH: 7.5 T: 22°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Aventis Pharma

LigandPNGBDBM14059(4-hydroxy-3-[[(3S)-2-oxo-3-(9-thia-5-azabicyclo[4....)
Affinity DataKi:  0.700nMAssay Description:Binding affinity against serine protease factor Xa (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTissue-type plasminogen activator(Human)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM14059(4-hydroxy-3-[[(3S)-2-oxo-3-(9-thia-5-azabicyclo[4....)
Affinity DataKi:  360nMAssay Description:Binding affinity against tissue plasminogen activator (t-Pa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine protease 1(Human)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM14059(4-hydroxy-3-[[(3S)-2-oxo-3-(9-thia-5-azabicyclo[4....)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity against trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine protease 1(Bovine)
Aventis Pharma

LigandPNGBDBM14059(4-hydroxy-3-[[(3S)-2-oxo-3-(9-thia-5-azabicyclo[4....)
Affinity DataKi:  1.00E+3nM ΔG°:  -8.10kcal/molepH: 7.5 T: 22°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetPlasminogen(Human)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM14059(4-hydroxy-3-[[(3S)-2-oxo-3-(9-thia-5-azabicyclo[4....)
Affinity DataKi:  2.30E+3nMAssay Description:Binding affinity against plasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Aventis Pharma

LigandPNGBDBM14059(4-hydroxy-3-[[(3S)-2-oxo-3-(9-thia-5-azabicyclo[4....)
Affinity DataKi: >4.00E+3nM ΔG°: >-7.28kcal/molepH: 7.5 T: 22°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Aventis Pharma

LigandPNGBDBM14059(4-hydroxy-3-[[(3S)-2-oxo-3-(9-thia-5-azabicyclo[4....)
Affinity DataKi:  4.00E+3nMAssay Description:Binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVitamin K-dependent protein C(Human)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM14059(4-hydroxy-3-[[(3S)-2-oxo-3-(9-thia-5-azabicyclo[4....)
Affinity DataKi:  5.20E+3nMAssay Description:Binding affinity against activated protein C (APC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed