BDBM142917 US10487086, Example I-115::US11136327, Example I-115::US8940720, I-115::US9802939, I-115

SMILES COC(=O)Nc1ccc2c(c1)NCCCCC[C@H](NC(=O)/C=C/c1cc(Cl)ccc1-n1cnnn1)c1nc-2c(C#N)[nH]1

InChI Key InChIKey=CCCHHBURCIOBJR-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 142917   

TargetCoagulation factor XI(Human)
Bristol Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 142917BDBM142917(US8940720, I-115 | US9802939, I-115 | US10487086, ...)
Affinity DataKi: <5nMAssay Description:The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2015
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Bristol Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 142917BDBM142917(US8940720, I-115 | US9802939, I-115 | US10487086, ...)
Affinity DataKi: <5nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 145 mM NaCl, 5 mM KCl, and 0.1% PEG 8000 (polyethylene glycol; JT Bake...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Bristol Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 142917BDBM142917(US8940720, I-115 | US9802939, I-115 | US10487086, ...)
Affinity DataKi: <5nMAssay Description:The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Bristol Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 142917BDBM142917(US8940720, I-115 | US9802939, I-115 | US10487086, ...)
Affinity DataKi: <5nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 145 mM NaCl, 5 mM KCl, and 0.1% PEG 8000 (polyethylene glycol; JT Bake...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2019
Entry Details
US Patent